That one is quite simple.
As you know, you get a "sureshot" if you have twice or more the attack of your opponent.
Hence, in a round with 2 cards with equals powers, if you put one pillz when your opponent doesnt put anything: you get a sureshot At the cost of only 1 pillz, it's worth it, no?
This one pillz can be very powerfull
It seems like a lot of people complain about random rooms. You know you can change your settings so that you only play non-random games, right? Just go to your account set-up screen, click the "Your Preferences" tab, and select "no random" from the drop-down box at the bottom. I haven't played normal mode in weeks because it was so infuriating.