Yup..if you just let something through because you're afraid of the card because it's big or has a huge power and a good bonus, you just might get nuked by that card because your opponent might have read you and just put a single pill in that card, more so even a fury..so don't just let things through easily..still, one of the safest way to deal with things like these is to put a pill or just block..because you don't always let a card through..specially if it can deal a huge amount of damage or can life steal you making him/her impossible to reach..
And one more thing..don't just let life-stealers or strong poison cards go through easily unless you have a SOA or SOB to counter their effects, in those cases, it's relatively safe to let those attacks through..otherwise, blockers / damage reducing cards can be used to reduce their damage and effects..
Well..that's why there are damage reducers..I only made Zatman an example assuming that you don't have a damage reducer in hand..because in most cases, players would not want to go head to head with a card like Zatman or Lyse Teria..and also, most of the time, players only put a few pillz on them too..that's why I also said "don't just let things through easily..still, one of the safest way to deal with things like these is to put a pill or just block..because you don't always let a card through..Remember..life is a resource..your opponent or you shouldn't and must not always go for a KO..having more life than your opponent is still a win..so use your life wisely.."
Zatman isnt really worthy of being blocked in most cases. For example, if you were to use Uranus, who has -5 opp damage, to block him, you'd have wasted part of that -5 because Zatman only has 4 attack. This is why most people let him through, and thus why most people dont put many pills on him. Which leads to my point that if someone plays Zatman, its a perfect chance to push a nuker through.
Well..that is the way I play, and these are just basic tips and guidelines anyway, I'm not saying it's mandatory that people follow what's written here..because different players mean different styles of play, and of course, situations must be weighed before making moves..(life points, card bonuses, what cards you and your opponent has, etc..) but what I'm saying here is..for me, I'd rather take a sure hit from cards like those if I don't have blockers and if my life points are still high rather than take the risk of going head to head with it (specially if my cards don't have the power or a good bonus or ability to deal with them) and risking to lose that round and have my pillz wasted because basically I don't know what's running inside the head of my opponent and he might have put pillz in it, and I don't want to just let my pillz go to waste in a round like that..not only have I took the risk of losing that round using my pillz to tackle a big card, but losing the whole match as well because I wasted precious pillz that I could've just conserved for other cards to use..for me..this is what I call "playing things safe"..but as I said..for others..things might be different, these are only mere tips for basic tactics..good games to all..
A lot of who you're willling to let through may also depend on who your opponent has in their hand in addition to who you may let through.
If your opponent has Zatman, Dorian, Ruby, Charlie in their hand... it might not be wise to just let Zatman through, if furied then they can kill you with any of their other cards no problem.(this hand contains 16 stars i know, but using Uppers/Pussycats it's a perfectly plausible hand.