Well i feel like i should shed some knowledge about 1hko's . Starting out i thought they were a huge deal. After some time i realized that 1hko's just weren't the best choice.
My advice is yeah they are neat to have and 1 hko will give you some wins early one but don't expect to get too far with them . They only work for a certain amount of time. Here are some tips for those still wanting to use them.
These may seem obvious to some but not to all.
Never go for the 1hko if your opponent has
A. Damage Reduction
B. SOA (Apply's to most except for Dacote
who is the opposite)
C. SOB ( Just for Fang Pi Clang
and La Junta
While it ends the game quickly, it may not be the smartest move to pull your 1hko out the very first round. It can end very badly for you if your opponent knows what they're doing. However there is some strategy that can be pulled out of this move.
A. You can bluff with a 1hko
B. You can put a decent amount of pills but not enough to activate the 1hko with fury. (Example 5 pills)
A. Bluffing can easily draw out your opponents pesky damage reduction / Soa cards. Its important to have good judgement as well. Remember Bluffing doesn't mean no pills. So don't be afraid to put a safety net of 1 or 2 pills.
B. Putting a decent amount can get you a whopping 9-10 damage in if it gets through. if your opponent thinks your going to go for the ko they will waste a nice amont of pills.