Synergy with the rest of the clan can be just as important in that case. But it is generally necessary to win a good number of matches with a majority 2-star draw if you're gonna have four of them in a deck.
That means either picking serious nukes as your other cards (risky), or concentrating on 2's that can kill.
, though they do have reliable 2-stars, will not kill you. Won't even come close, really, and one nuke probably won't make the difference.
, with their effective two-stars + Poison, can most definitely kill, and a perceived necessity to hit on the first hand can lead to a lot of bluff opportunities.
can completely shut their opponents down, depending on the hand. Getting that damage through is a pain, though.
can most definitely kill you on pure damage, backed up by their tricky bonus. Attack manipulation hurts bad, however.
Sentinels can easily take on an equivalently-starred hand, but may run into trouble in the damage department if they get too much opposition. Same with Piranas
Personally, I would choose either Freaks
. I must admit, however, that I don't have a terrible amount of experience with some of the other clans.