Using 8-10 pills on your first go with Grudj or Karrion is NOT a strategy. That is to say, it is a strategy, but takes no strategic thought to pull off. Please stop rewarding idiot players a decent elo standing for playing like this, and get rid of Grudj and Karrion.
Seriously, there are cards out there that I groan on seeing, but can still have fun playing against. Then there are these two, that just sap any fun out of the match, because I know that I might pay really well and still lose to a moron.
I know it can be frustrating to lose to that opener... However, I think trying to nuke with Grudj or Karrion is a valid strategy, since the player who attempts to do so puts himself in a very risky situation, and needs to be able to wall to succeed.
There are two relatively reliable counter-strategies.
1) Build your deck with at least 4 good nukes. I would recommend doing this whenever possible. That way you can usually respond to such an opener as if you were certain it was a low-pill bluff, using one of your lower damage cards. If your opponent used a lot of pills, odds are you can simply counter.
2) Try to read your opponent's opener by looking at his walls and his damage sources. Does your opponent have a bunch of low-damage DR/wall cards and one big strong poisoner? In all likelihood, he will attempt to land the poisoner in R1 at any cost, so respond accordingly.
Guess it's my luck that I rarely see such a combos.
Personally, I would keep some walls in my deck, and some defeat's abilities to assist me in suicidal against such pests.
Attack manipulators also would help a ton for consuming lesser pills after that opener, giving chance to counter the life gap.
I was under that same assumption, ghelas, only to find out that oaths are broken in the name of victory.
Bogdan and Grudj (Bogrudj, if you will) are ELO's most fearsome dynamic duo IMO, edging out MokrAnus, Beester Cr, Pean, DagXodus, MarSaki, AvolaGhi, CloiAna, Clidg, RaveLena, etc. Okay I just wanted to have fun with those.