It really depends on how the wheel itself is programmed.
Quite likely, it is pure random in each slot. If so, that means your odds of winning are set per ticket, using more lines at a spin is just saving you some clicks.
Since I have yet to detect any pattern in the wheels at all, I would say that this is a fair assumption.
Thus, doing 3 at a time saves you clicks, and avoids the psychological horror of having grand prize show up on a line you neglected to use.