I say the best combat strategy is to play the most pills for the character you think is the best. One you think might be the strongest or might have the best ability. Feel free to tell me in the comments what your best combat strategy is. If I can, I'll try it.
I allways play 0 pillz on my best character so he loses
Now back to being sensible playing pillz on your best card is good but using too many can leave you at a big disadvantage.
My best combat strategy is to make sure I have more life than my opponent at the end of the 4th round. It's simple, but surprisingly effective.
My very simple strategy is to KO as quickly as possible. Please teach me how to play im not anywhere near your level. Seriously dude. Tell me your deck via PM and i will tell u the best way how to use it. I can also do pratice battles with you so you can get warmed up
Awwww c'mon guy. I don't overpill my best card I conserve pills and chip away my opponent's life and pillz until I think I can seal the deal with a big enough move, then back it up with damage reducers and such.