Post your top three 2-star cards and explain why =)
1. Spiaghi - 7 power is good enough to wall for a 2 star, but the ability to reduce 3 damage at minimum 1 is amazing. Splashable in any deck if you need DR or if you need more stars for other cards.
2. Jessie - 7/2 +2 life. With the clan bonus she can match with 9-powered cards. Can also widen the life gap 4 to 6 points.
3. Hawkins - 7/2 -2 pills min 1. Like Spiaghi, Hawkins is also splashable in any deck. The -2 pill brings in and open up lots of strategies. The -2 pill can pressure your opponents to overpill on most rounds.
I find Wardog & Esmeralda pretty useful. They get the most run for 2 stars with me. Esmeralda is good for forcing an opponent to use a pill or winning when you both are out of pills with her +10. And Wardog has 8 strength & +2 Bonus making him 8/4 which is pretty handy.
I think all of the ones mentioned are good, but I think Phyllis was left out. She's a 7/1 with -3 life, she doesn't have K.O. ability, but she she is strong enough to get around most damage reducers, and give you a good start. Vulnerable to S.O.A, but with her S.O.B she works against Roots or GHEIST.