No right answer, some clans do better with the first option, others with the second and some other others with a third unlisted option.
It depends on the clan, play style of you and many other factors. There are many other combos though, some people even go with 5/4/4/4/2/2/2/2 Or 4/4/4/4/3/2/2/2.
I usually run 5/4/4/3/3/2/2/2 but thats all dependent on the clan I'm using. I usually reserve that 5* slot for a Leader too, especially when using Uppers since they have some really powerful 4 stars.