"What the point of pay over 50k for Dregn just to have him lose to 2 star*"
Its matter of 8 damage vs 2 damage on same pills. You can afford to put 0-7 pills to Dregn and still win the game even if opponent doesnt pill at all. if you put 7 pills to say - Lehane - to win Dregn you are quite guaranteed to lose the game if opponent pilled 0. Lehane's damage just wont make you win game, but Dregns damage justifies a lot of pills.
And even if you lose with high pills - opponent used a lot of pills to beat you - so you are again somewhat equal.