It really depends on the opponent hand. if they have a damage reducer, there is a higher chance that they will Tank
if they have a defeat card, there is a higher chance they will Tank
if they have a revenge card, and one of the other types mentioned previously...
chances are even higher that they will Tank
of course it all depends on the player.
some players will use the fact that they have defeat, revenge, and damage reducers against you.
it all comes down to... how much risk you're willing to manage.
if they have a reducer, if you go 0 pillz, and they win, will it force you to be on the defensive?
because if they're good, lucky, or otherwise able to thwart your moves, you'll have to play more spontaneous.
if they have all defeat/reducer cards... then it's a gamble... it's always a gamble.
it's a dog eat dog world out there.