Typically with Vortex
you want to 3 or 4 pill on the first guy if you don't think the enemy is bluffing, but only 1 or 2 pill if you do think they are. If you cannot tell, 1 pill.
If you hit them on first round, let second round fly straight through, just 1 pill and get the rebate. If you did NOT hit on first round, pill a little high (5 or 6) unless you are certain they are bluffing, then do 2 or 3 just incase you were wrong.
Third round, if you can get a kill (or enough life gap to ensure a win) go full pillz. Either you land it, or they run out of pillz and you get to land the last one for free (probably with fury).
Mostly, with Vortex
you just NEED to properly predict your opponent, or play semi-aggressive in each round. The worst thing you can do is put too many pillz on a card that doesn't get you a significant advantage though. If you slap out 8 pillz and do 3 damage, you just lost the round.
If lucky enough to draw all 3, one awesome combo is:
So you take a loss but do 2 damage anyway and gain a pill advantage. Then you get a fairly easy win with a 6 point life difference (both revengers are basically 8/6 when revenge is activated), and another pretty easy win for 4 more points of life. With Lehrg
that means they are dead (without DR), and with Kronnen
it means they cannot make up the life difference even with Fury.