Normally Skeelz do well against those types of deck. What cards are you using? However to answer your questions.
Q-A) No if anything it will compound the problem. Both are heavy pill investment clans.
Q-B)It can work it will just be difficult. Maybe Montana/Junkz to help win some low pill rounds would be beneficial.
However in general they play better in mono.
Skeels tend to have high base power and some real good support: atk manip cards.
I find that their half decks are also very good and they could work with most other clans.
They COULD work with fang pi, but not that well imho. Get some high power Skeelz or some atk manip ones and pair em up with hard hitting fang pi so that you constantly have a 2HKO threat that might force the enemy to overpill or something.
basically what Fanta is saying is also a real good idea and the Uppers work too since Montana/Junkz/Uppers have decent damage cards that pose that 2HKO threat and the enemy knows that they gotta pill when you play the atk manip cards otherwise you can 2HKO them will all your pills on the following round
TL/DR: Skeelz are quite versatile, just make sure to always try to pose a 2HKO threat to make the enemy quiver with fear