For me, the best 2* is Steve (if not against SOA).
Steve with 3 pills, 27 attack.
You need to pill more to beat him, while your damage reduced.
Steve is in a WIN-WIN situation. Throw him off with 3 pills, your opponent's card gets reduced damage, or take three damage, which is essential to any mindgames; your card need to be pilled just to beat this card, but with 2 reduced damage.
Neloe is actually the worst of the bunch in terms of actual DR. -3 damage is nice but minimum of 3 still lets by most damage from an average card. the min of 3 is probably to balance the fact that you get 2/3 pills back with vortex bonus