Well... that kinda only works if you've got the 2HKO potential.
imho if you make sure you got DRs and eugene as well as some atk manip cards (for low pill battles), you should be able to play with more options in regards to pill usage. It's about making sure your deck has enough utility to overcome the opponent. Having SOA and SOB may also help
IMO they do best in DM t2 get your hands on the best one (as a colossus im assuming you have them already) throw ambre in there and just be careful not to overpill alot of your deck should have 9-10 power without trying so your at an advantage even vs some bangers alot of players psych themselves out vs cards like tan man and selena when they have ambre backing them up so count on that as well you should do fine