Lakit+ any skakhrom with 2 damage= win (4 in Elo)"
Barring Soa, + life, multiple high damage hits, dr and Sigma. Which is a lot of stuff.
In regards to the original topic, no. Poison and Defeat: - life affect the player that's still conscious, hence there's nothing interrupting it. Being out cold is enough to warrant a loss instantly. End of story. But then again, FR has a resurrection card out...