Try the freaks. This the only mode theyre actually competitive in. Don't try to get your poison off 1st round. 2nd round poisons are more likely with this clan because players typically try to match your pills or bluff you with 1 pill making the gamble not worth the investment. 3 to 4 pillz in the 1st round is good but never 7+ pillz. I've seen many freak players do this and it's hilarious when i 1 pill them.
Try to get power or attack manipulators in your deck so your opponent will be pushed to use more pillz for a payout on damage. This gives you the chance to study how players strategize in EFC. What cards typically get priority over the rest? What is the enemies strongest card? Most players bluff poweful cards and chip away with weaker cards. Others may put fury on a weaker card to K.o or trick you into under pilling. When going against attact manipulation clans, never 1 pill your character. Always try to put at least 3 or 4 pillz down in case they do a 1 or 2 piller to get some cheap damage off.
TLDR: the best DRs in the game are free of charge. It's called winning the round. The freaks typically have very high power to help you win rounds and are resilient to dr's because of their poison bonus. Remember, if You win the round, you take little to no damage and get to deal your damage and set your poison. It costs pillz but make it count when you use them.
I was running a Freaks/Riots deck with an 80% winrate over the course of the 10 games that I played. I HAD A LOT OF FUN! Like... So much fun xd Freaks is something I hadn't tried before but they're actually pretty strong.
Strategies change a lot based on matchup so saying that 1 specific play is good is kinda not really right, as sometimes playing 9 on Bikini Joe Ld round 1 is the correct play, it really depends. I matched with Riots because that way I could afford to overpill to get the poison in.